Epub 2020 Jun 15. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. CROI 2014: Advances in antiretroviral therapy. Olender S, Wilkin TJ, Taylor BS, Hammer SM. At baseline, half were taking NNRTI-based regimens, a third were taking integrase inhibitors and 17% were o… CROI 2014: Advances in antiretroviral therapy. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. CROI 2018: Advances in Antiretroviral Therapy. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. USA.gov. In FLAIR, people who were treatment-naive were started on abacavir/dolutegravir/lamivudine (Triumeq) and, if they achieved viral suppression at 20 weeks, were randomized to either stay on this oral regimen or add oral CAB and RPV (to demonstrate … Epub 2020 Jun 15. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. N Engl J Med 2019 Jul 24. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). This site needs JavaScript to work properly. Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. eCollection 2020. To date, women have been less represented than men in LA ART research. COVID-19 is an emerging, rapidly evolving situation. J Subst Abuse Treat. Creation of a long-acting rilpivirine prodrug nanoformulation. More information: Morgan M. Philbin et al, A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across … This strategy — two injections every 4 or 8 weeks — obviates the need to take antiretroviral therapy daily. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). HHS First long-acting injectable antiretroviral therapy for HIV recommended for approval EMA has recommended the granting of marketing authorisations for two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in The Lancet.1 They compared … 4,5,6 Cabotegravir and rilpivirine are co-administered as two intramuscular (IM) injections in the buttocks by a Healthcare Professional at the … CROI 2016: Advances in Antiretroviral Therapy. COVID-19 is an emerging, rapidly evolving situation. The … The first long-acting injectable treatments for HIV were recommended for marketing approval on October 16 by the European Medicines Agency (EMA). 2019 Oct 26. doi: 10.1007/s10461-019-02701-7. With long-acting injectable antiretroviral therapy likely to be a treatment option for people living with HIV (PLWH), it is critical to assess its acceptability among potential end-users. Emerging alternative antiretroviral (ARV) delivery systems for HIV treatment and prevention include injectables, topicals, and implants. Top Antivir Med. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. Based on formative qualitative work and our own ongoing development of targeted long-acting products in nanosusp … Creation of a long-acting rilpivirine prodrug nanoformulation. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency . In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. A third were women, two thirds were white, about a quarter were black and the median age was 42 years. J Control Release. They had been on antiretroviral therapy for a median of four years, all had viral suppression and the median CD4 count was 653 cells/mm3. Top Antivir Med. Likert scores of long-acting injectable antiretroviral therapy acceptability by proposed injection-site reaction duration. Olender S, Wilkin TJ, Taylor BS, Hammer SM. The compound also exhibits activity against HIV-2. Theranostics. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs). eCollection 2020. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. Read on to learn more about the new drug and what to consider ahead of its potential arrival in early 2021. NIH Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. A clinical trial to evaluate long-acting antiretroviral therapy (ART) for maintaining HIV suppression in people for whom adhering to conventional daily oral ART has been a challenge has begun at research sites across the United States. The data supporting a regimen consisting of injectable CAB/RPV were presented at CROI 2019 in the form of a pair of open-label trials named FLAIR and ATLAS. July 30, 2019. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in . Theranostics. Taylor BS, Olender SA, Tieu HV, Wilkin TJ. USA.gov. Cabenuva, pending FDA approval, stands to impact HIV treatment in the U.S. Cabenuva would be the first injectable antiretroviral. Maturation inhibitor. | Whilst ART does not cure HIV and AIDS, and should therefore be taken for life, it dramatically reduces mortality and morbidity if used appropriately. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery, Nature Communications (2019). 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